Celebrex is a trade name of Celecoxib. This ingredient provides an analgesic, anti-febrile, and anti-inflammatory action.
Celebrex has a good absorption from the gastro-intestinal tract. The maximal concentration of the drug is achieved in 2-3 hours during the peroral use. Food may slow down the uptake but at the same time, food reduces a risk of the side effects in the gastro-intestinal tract.
Unlike other non-steroid anti-inflammatory drugs, Celebrex selectively inhibits the action of COX-2 and does not influence on COX-1. It keeps the natural processes in the gastro-intestinal tract and reduces a formation of ulcers and erosions.
Celebrex gives good results in the treatment of such diseases as:
- Rheumatoid arthritis
- Deforming osteoarthritis
- Pain syndrome of medium intensity
According to the results of the recent medical studies, Celebrex shows a therapeutic activity during neoplasms of large bowel and may prevent a development of cancer.
In what dose is Celebrex used?
Celebrex is produced in capsules for the oral use which may contain 100 mg or 200 mg of Celecoxib. It is recommended to take Celebrex in the minimal working dose in order to reduce its side effect. Therefore, patients are prescribed a minimal dose of Celebrex and gradually increase it.
The optimal therapeutic dose of Celebrex is 200 mg 2 times per day during the treatment of the inflammatory diseases of the locomotor system.
In case of the acute condition of arthritis or arthrosis with severe pain, a dose of Celebrex may be increased up to 4 capsules 200 mg per day (a capsule of Celebrex 200 mg every 4-5 hours).
As a development of the complications in the cardiovascular system directly depends on a dose, Celebrex should be prescribed for a short period, and the dose should be lowered if the medical improvements appear. Senior patients and patients with light diseases of the cardiovascular system should take Celebrex 100 mg 2-4 times per day.
- Do not take Celebrex during the acute condition of the ulcer in the stomach and duodenum
- The use of Celebrex is not recommended during thrombocytopenia, heart failure, cardiac arrhythmias, and uncontrolled hypertension
- Celebrex is not prescribed patients who have had a coronary artery bypass surgery
- If you are pregnant, breast-feeding, or under 18 years old, do not take Celebrex
- Avoid alcohol consumption, spicy/fatty food, or products increasing the irritation of the mucous membranes of the gastro-intestinal tract during the use of Celebrex
The side effects are not observed during the short-term use of Celebrex in low doses. But in case of the use of higher doses of Celebrex within a long time, various side effects may appear: flatulence, dyspepsia, peripheral edema, insomnia, anemia, and tinnitus.
Some patients may have high blood pressure or increased heartbeat. If you noticed negative symptoms in the heart after the use of Celebrex, stop the treatment and visit a doctor.